6 research outputs found
25th annual computational neuroscience meeting: CNS-2016
The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong
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Rule discovery performance unchanged by incentives
Human behavior is modulated by financial incentives, but it is not well understood what types of behavior are immune to incentive and why. The cognitive processes underlying behavior appear to create restrictions on the effect an individual's motivation will have on their performance. We investigate a classic category learning task for which the effect of financial incentives is still unknown (Shepard, Hovland, & Jenkins, 1961). Across four renditions of a category learning experiment, we find no effect of incentive on performance. On a fifth experiment requiring category recognition but not learning, we find a large effect on response time and small effect on task performance. Humans appear to selectively apply more effort in valuable contexts, but the effort is disproportionate with the performance improvement. Taken together, the results suggest that performance in tasks which require novel inductive insights are relatively immune to financial incentive, while tasks that require rote perseverance of a fixed strategy are more malleable
Stimulus Pauses and Perturbations Differentially Delay or Promote the Segregation of Auditory Objects: Psychoacoustics and Modeling
Segregating distinct sound sources is fundamental for auditory perception, as in the cocktail party problem. In a process called the build-up of stream segregation, distinct sound sources that are perceptually integrated initially can be segregated into separate streams after several seconds. Previous research concluded that abrupt changes in the incoming sounds during build-upâfor example, a step change in location, loudness or timingâreset the percept to integrated. Following this reset, the multisecond build-up process begins again. Neurophysiological recordings in auditory cortex (A1) show fast (subsecond) adaptation, but unified mechanistic explanations for the bias toward integration, multisecond build-up and resets remain elusive. Combining psychoacoustics and modeling, we show that initial unadapted A1 responses bias integration, that the slowness of build-up arises naturally from competition downstream, and that recovery of adaptation can explain resets. An early bias toward integrated perceptual interpretations arising from primary cortical stages that encode low-level features and feed into competition downstream could also explain similar phenomena in vision. Further, we report a previously overlooked class of perturbations that promote segregation rather than integration. Our results challenge current understanding for perturbation effects on the emergence of sound source segregation, leading to a new hypothesis for differential processing downstream of A1. Transient perturbations can momentarily redirect A1 responses as input to downstream competition units that favor segregation
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Abnormal Capillary Vasodynamics Contribute to Ictal Neurodegeneration in Epilepsy.
Seizure-driven brain damage in epilepsy accumulates over time, especially in the hippocampus, which can lead to sclerosis, cognitive decline, and death. Excitotoxicity is the prevalent model to explain ictal neurodegeneration. Current labeling technologies cannot distinguish between excitotoxicity and hypoxia, however, because they share common molecular mechanisms. This leaves open the possibility that undetected ischemic hypoxia, due to ictal blood flow restriction, could contribute to neurodegeneration previously ascribed to excitotoxicity. We tested this possibility with Confocal Laser Endomicroscopy (CLE) and novel stereological analyses in several models of epileptic mice. We found a higher number and magnitude of NG2+ mural-cell mediated capillary constrictions in the hippocampus of epileptic mice than in that of normal mice, in addition to spatial coupling between capillary constrictions and oxidative stressed neurons and neurodegeneration. These results reveal a role for hypoxia driven by capillary blood flow restriction in ictal neurodegeneration